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Multivariate resting-state functional connectivity predicts response to cognitive behavioral therapy in obsessive – compulsive disorder

Authors: Nicco Reggente, Teena D. Moody, Francesca Morfini, Courtney Sheen, Jesse Rissman, Joseph O’Neill and Jamie D. Feusner Article: PDF | Supporting Information Plain English: In this work, we collected Resting-State fMRI data from patients with OCD before they engaged in 4 weeks of Cognitive Behavioral Therapy (CBT). We calculated functional connectivity within the Default […]

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Shared and distinct contributions of rostrolateral prefrontal cortex to analogical reasoning and episodic memory retrieval

Andrew Westphal, Nicco Reggente, Kaori Ito, Jesse Rissman Abstract: Rostrolateral prefrontal cortex (RLPFC) is widely appreciated to support higher cognitive functions, including analogical reasoning and episodic memory retrieval. However, these tasks have typically been studied in isolation, and thus it is unclear whether they involve common or distinct RLPFC mechanisms. Here, we introduce a novel […]

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Decoding fMRI Signatures of Real-world Autobiographical Memory Retrieval

Jesse Rissman, Tiffany E. Chow, Nicco Reggente, and Anthony D. Wagner Abstract: Extant neuroimaging data implicate frontoparietal and medial-temporal lobe regions in episodic retrieval, and the specific pattern of activity within and across these regions is diagnostic of an individual’s subjective mnemonic experience. For example, in laboratory-based paradigms, memories for recently encoded faces can be […]

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Episodic memory retrieval benefits from a less modular brain network organization

Westphal, A.J., Monti, M.M., Reggente, N., Yazdanshenas, O., & Rissman, J. Andrew Westphal presented this work at an SfN Nanosymposium in Washington D.C (2014) SfN 2014 Abstract: The act of retrieving a memory for a specific episode of one’s past requires the coordination of brain networks involved in controlling access to mnemonic contents and representing […]

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The Ethics of Neuromodulation for Consciousness Exploration

In 1641 Rene Descartes sat, ball of wax in hand, pondering the flexibility of material states and how such impermanence spoke to an object’s essence. Hundreds of years later, cognitive neuroscientists are probing into the recesses of the human brain, assessing its task-dependent states, and forming hypotheses regarding the underpinnings of its malleability. Just like […]

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Characterizing common and dissociable involvement of medial temporal lobe regions during episodic source memory retrieval and analogical reasoning

Westphal, A.J., Reggente, N., Ito, K., Fortuna, W.H., Nawabi, Y., Milstein, M., & Rissman, J. SfN_2013_Poster  SfN 2013 Abstract Episodic memory and analogical reasoning tasks tend to engage many common frontoparietal structures, perhaps owing to their common demands for declarative memory retrieval and relational integration. Regions of the medial temporal lobe (MTL), well known to […]

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Decoding cognitive task-sets from rostral prefrontal cortex functional connectivity patterns

Westphal, A.J., Reggente, N., Ito, K., Fortuna, W., & Rissman, J. HBM_2013_Poster  HBM 2013 Abstract Resting state fMRI connectivity analyses have identified a number of distinct functional brain networks, including the fronto-parietal task control network (FPTCN), the dorsal attention network (DAN), and the default mode network (DMN) (e.g., Vincent et al., 2008, Power et al., […]

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Shared and distinct contributions of rostral prefrontal cortex to analogical reasoning and episodic memory retrieval: Insights from fMRI functional connectivity and multivariate pattern analyses

Westphal, A.J., Reggente, N., Nawabi, Y., & Rissman, J. CNS_2013_Poster CNS 2013 Abstract   The rostral prefrontal cortex (RPFC), positioned at the apex of the prefrontal processing hierarchy, has been implicated in a diverse array of high-level cognitive processes including analogical reasoning and episodic memory retrieval—tasks that may share demands for relational integration. However, because […]

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Predicting individual differences in cognitive gains from videogame training using machine learning analyses of fMRI functional connectivity patterns

CNS 2014 Abstract: Nikolaidis, A., Reggente, N. et al Summary: Using the the task-dependent functional connectivity across nodes within established cortical network from both before and after videogame training, we were able to asses the “plasticity” of these networks as a function of training. The plasticity of these networks, combined with graph theoretical metrics were […]

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Memory recall for high value items correlates with individual differences in white matter pathways associated with reward processing and fronto-temporal communication

Publication: Coming Soon SfN 2013 Poster: Reggente_SfN_2013 Summary: We used DTI to explore anatomical accounts for individual differences in the behavioral effects of value-directed remembering. We examined connectivity within the mesolimbic system by using probabilistic tractography algorithms to compute anatomical connectivity between each subject’s nucleus accumbens(NAcc) and ventral tegmental area(VTA). We also extracted mean fractional anisotropy […]

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