Neuroscience Category

The potential importance of neural recurrence for motion perception

A natural intuition emerges when one becomes versed in the sensory transduction mechanisms of the human brain: information that was once observer-independent can be continually translated and interpreted along hierarchical processing streams so as to eventually represent that sensory stimuli by way of a unified subjective experience. In a conceptually similar manner to the refinement […]

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Coluracetam’s Pharmacological Mechanisms: A Perspective Piece

Reference: ___________________________________________________________________________ IUPAC: N-(2,3-dimethyl-5,6,7,8- tetrahydrofuro[2,3-b] quinolin-4-yl)-2- (2-oxopyrrolidin-1-yl)acetamide Molecular Formula: C19H23N3O3 Aliases: BCI-540; MKC-231  ___________________________________________________________________________   Background: Coluracetam, initially synthesized in Japan, was first introduced to the scientific research community in 1993 as a choline uptake enhancer that selectively affected memory-related mechanisms23. Coluracetam’s mechanisms of action and specific behavioral effects were investigated by the Mitsubishi Tanabe […]

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Thalamocortical Connectivity Predicts Level of Awarness in Disorders of Consciousness

Zheng, Z., Reggente, N., Lutkenhoff, E., Owen, A., Monti, M. Amy Zheng presented this poster at SfN in Washington, D.C (2014) SfN 2014 Poster Brief: In this study we used probabilist tractography on diffusion tensor imaging data to look at the whole brain’s anatomical connectivity index with the Left and Right Thalamus for patients with […]

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Episodic memory retrieval benefits from a less modular brain network organization

Westphal, A.J., Monti, M.M., Reggente, N., Yazdanshenas, O., & Rissman, J. Andrew Westphal presented this work at an SfN Nanosymposium in Washington D.C (2014) SfN 2014 Abstract: The act of retrieving a memory for a specific episode of one’s past requires the coordination of brain networks involved in controlling access to mnemonic contents and representing […]

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The Ethics of Neuromodulation for Consciousness Exploration

In 1641 Rene Descartes sat, ball of wax in hand, pondering the flexibility of material states and how such impermanence spoke to an object’s essence. Hundreds of years later, cognitive neuroscientists are probing into the recesses of the human brain, assessing its task-dependent states, and forming hypotheses regarding the underpinnings of its malleability. Just like […]

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Individual differences in working memory performance as a function of the local integrity and regional connectivity of the hippocampus

Very proud of my research assistants(first and second authors) putting this one together! 2014_UCLA_Science_Day_Poster Kommers, C.1,+, Raccah, O.1,+, Reggente, N.,1 Rissman, J1,2 Although the hippocampus is well known to contribute to the storage and retrieval of long-term memories, emerging data suggests that the hippocampus may also contribute to the online maintenance of task-relevant representations in […]

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Characterizing common and dissociable involvement of medial temporal lobe regions during episodic source memory retrieval and analogical reasoning

Westphal, A.J., Reggente, N., Ito, K., Fortuna, W.H., Nawabi, Y., Milstein, M., & Rissman, J. SfN_2013_Poster  SfN 2013 Abstract Episodic memory and analogical reasoning tasks tend to engage many common frontoparietal structures, perhaps owing to their common demands for declarative memory retrieval and relational integration. Regions of the medial temporal lobe (MTL), well known to […]

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Decoding cognitive task-sets from rostral prefrontal cortex functional connectivity patterns

Westphal, A.J., Reggente, N., Ito, K., Fortuna, W., & Rissman, J. HBM_2013_Poster  HBM 2013 Abstract Resting state fMRI connectivity analyses have identified a number of distinct functional brain networks, including the fronto-parietal task control network (FPTCN), the dorsal attention network (DAN), and the default mode network (DMN) (e.g., Vincent et al., 2008, Power et al., […]

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Shared and distinct contributions of rostral prefrontal cortex to analogical reasoning and episodic memory retrieval: Insights from fMRI functional connectivity and multivariate pattern analyses

Westphal, A.J., Reggente, N., Nawabi, Y., & Rissman, J. CNS_2013_Poster CNS 2013 Abstract   The rostral prefrontal cortex (RPFC), positioned at the apex of the prefrontal processing hierarchy, has been implicated in a diverse array of high-level cognitive processes including analogical reasoning and episodic memory retrieval—tasks that may share demands for relational integration. However, because […]

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MVPA (Multi Variate/Voxel Pattern Analysis): The Basics

Often times I feel restrained by the unfortunate, inherent shortcomings of medical and functional imaging data. The entire process is subject to a vast array of variability, assumptions, and “warpings” in many senses of the word. These, however minute the calculations and interpolations may be, carry an overarching sentiment of being haphazard. However, differences between […]

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